Abbreviations

Targets

Abbreviation	Description
Abl	V-abl Abelson murine leukemia viral oncogene homolog 1
ALK	anaplastic lymphoma kinase
ATM	Ataxia telangiectasia mutated
B-Raf	B-Raf proto-oncogene serine/threonine-protein kinase (B-RAF), also known as V-raf murine sarcoma viral oncogene homolog B1
Bcl-2	B-cell lymphoma 2
bcr	breakpoint cluster region
Caspase	cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases
CCR5	co-receptors chemokine receptor 5
CDK	Cyclin-dependent kinase
CFTR potentiator	Cystic fibrosis transmembrane conductance regulator
CTSK	Cathepsin K, abbreviated CTSK
c-Kit	CD117, also called KIT or C-kit receptor
c-Met	mesenchymal-epithelial transition factor
DNA-PK	DNA-dependent protein kinase
DPP-4	Dipeptidyl peptidase-4
EGFR	Epidermal growth factor receptor
Factor Xa	also known by the eponym Stuart-Prower factor or as prothrombinase
FGFR	Fibroblast growth factor receptor
FLT-3	fms-like tyrosine kinase receptor-3
FTS	farnesyl thiosalicylic
GSK-3	Glycogen synthase kinase 3
HER2	Human Epidermal growth factor Receptor 2
Hedgehog	an intercellular signaling molecule called Hedgehog (Hh)
HDAC	Histone deacetylase
HIF	Hypoxia-inducible factor
HSP-70	heat-shock protein-70
HSP-90	heat-shock protein-90
IGF-1R	Insulin-like growth factor 1 receptor
JAK	Janus kinase
JNK	c-Jun N-terminal kinases
Ksp	Kinesin spindle protein
MAPK	Mitogen-activated Protein Kinase
MEK	MAPK/ERK kinase
mGlu2/3 receptors	metabotropic glutamate receptors
mTOR	Mammalian target of rapamycin
NF-kB	Nuclear factor κ B
p38 MAPK	p38 Mitogen-activated Protein Kinase
p53	protein 53 or tumor protein 53
PARP	Poly (ADP-ribose) polymerase
PDGFR	platelet-derived growth factor receptor
PDK-1	phosphoinositide-dependent kinase-1
Rho	ρ factor
PI3K	Phosphatidylinositol 3-kinases
PKC	protein kinase C
PLK	Polo-like kinase
Ras	renin-angiotensin system
RNA Polymerase I	RNAP or RNApol
S1PR1	sphingosine-1-phosphate receptor 1，also known as S1P1 or EDG1 (endothelial differentiation gene 1)
sPLA2	Secreted phospholipases A2
Src	Rous sarcoma oncogene cellular homolog
Stat	Signal Transducers and Activator of Transcription
Survivin	also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5
TGF-beta	Transforming growth factor
TNF-alpha	Tumor necrosis factors
VEGFR-PDGFR	Vascular Endothelial Growth Factor Receptor -platelet derived growth factor receptor
Wee1	Small cell protein, a mitotic inhibitor kinase
Wnt	a combination of Wg (wingless) and Int

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