RU58841 UPDATE

RU58841

We have historically focused on Androgen Receptor agonist compound research, but RU58841 is the first androgen receptor antagonist compound we have synthesized.

RU58841 is a nonsteroidal antiandrogen (NSAA) investigated for potential use as a topical treatment for androgen-dependent conditions including pattern hair loss.

With scalp application, RU58841 works by binding to the androgen receptor in the hair follicle. As a result androgens are prevented in binding to AR’s and start the chain reaction of androgenetic alopecia causing miniaturization of follicles.  This disruption only occurs at a local level at the site of application so systemic effects are avoided.

Comparison to other pathways:

In comparison to finasteride (which is a 5α-reductase inhibitor,  inhibiting DHT on a systematic elvel), anagen follicles increased an average of 88% compared with dosing compared to 103% with dosing of RU58841 (5%).

Growth of vellus follicles to terminal size was 12% with finasteride , and 26% with RU58841 (5%).

Serum DHT decreased about 70% with finasteride, but exhibited no significant changes with RU58841.

Summary of RU58841:

-Strongly competes against DHT at the AR

-Imparts increased net follicle growth in comparison to 5α-reductase inhibitors

-Increases cellular replication rate in follicle matrix cells

-Increases cellular proliferation of follicle outer root sheath cells

-Increases follicle diameter and density

-Increases total anagen phase percentage

-Exerts no negative effects on systematic DHT levels

Generally applied topically to AA subject areas such as the top of the scalp, 1ml of 5% solution

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RU58841

50ml  |  50mg/ml  |  5%  |  (50 x 50mg )

M.Wt: 369.34 Formula: C₁₇H₁₈F₃N₃O₃ 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile Solubility: Polyglycols, Aqua, Ethanol Purity: >99% Storage: at 5℃ 3 years Half life: 24 hours CAS No.: 154992-24-2

was last modified: January 29th, 2025

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